منابع مشابه
Smad signalling network.
Dimeric ligands of the transforming growth factor β (TGF-β) superfamily bind with high affinity to type II and type I receptor serine/threonine kinases on the cell surface and induce hetero-tetrameric receptor complexes. In such complexes, constitutively auto-phosphorylated type II receptors (green) trans-phosphorylate (arrows) the type I receptor (blue) GS domain. Activated receptors recruit a...
متن کاملSmad signalling in the ovary
It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily. In the ovary, several TGF-beta superfamily members are expressed by the oocyte, granulosa and thecal cells at different stages of folliculo...
متن کاملSystems theory of Smad signalling.
Transforming growth factor-beta (TGFbeta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGFbeta signalling are the Smad proteins, which upon TGFbeta stimulation accumulate in the nucleus and regulate the transcription of target genes. To investigate the mechanisms of Smad nuclear accumulation, we developed a simple mathemat...
متن کاملTGFbeta-Smad signalling in postoperative human lens epithelial cells.
AIMS To localise Smads3/4 proteins in lens epithelial cells (LECs) of fresh and postoperative human specimens. Smads3/4 are involved in signal transduction between transforming growth factor beta (TGFbeta) cell surface receptors and gene promoters. Nuclear localisation of Smads indicates achievement of endogenous TGFbeta signalling in cells. METHODS Three circular sections of the anterior cap...
متن کاملReversible ubiquitination regulates the Smad/TGF-β signalling pathway
TGF-β (transforming growth factor-β) signals through serine/threonine kinase receptors and intracellular Smad transcription factors. An important regulatory step involves specific ubiquitination by Smurfs (Smad– ubiquitin regulatory factors), members of the HECT (homologous to E6-associated protein C-terminus) ubiquitin ligase family, which mediate the proteasomal degradation of Smads and/or re...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2002
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.115.17.3355